Salmon fibrin stimulates greater proliferation and differentiation of human neural stem/progenitor cells (hNSPCs) than mammalian fibrin

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Neuron differentiated from hNSPCs in salmon fibrin/ hyaluronic acid gel.

Salmon fibrin SEA-133 and SEA 135, is a unique non-mammalian ECM that supports proliferation and differentiation of human neural stem/progenitor calls (hNSPCs), adipose-derived stem cells, and other stem cells. This ECM from the plasma of farmed salmon, stimulates greater hNSPC proliferation than mammalian fibrin, and enhances vascularization. Salmon fibrin is biocompatible, polymerizes in situ, and is free of mammalian pathogens. Combination scaffolds of salmon fibrin and hyaluronic acid generate compliant hydrogels matching the physical  properties of brain tissue.

For more information see: Arulmoli et al. Acta Biomaterialia 2016).